Postbiotics supplements may be a new term to many, yet they are as beneficial for the body as pre- or probiotics. Short-chain fatty acids (SCFAs) are postbiotic compounds that are important for metabolism and digestive health, and work to support a healthy microbiome by mediating microbe-to-host-immune system crosstalk between the gut and the brain. Prime™ Advanced Digestive Support is a gluten-free, non-GMO, vegan botanical blend of amino and fatty acids formulated to support gut health, metabolic health and cognitive health through healthy SCFA postbiotic production.

Gluten-Free – The finished product contains no detectible gluten (<10 ppm gluten)

No Detectable GMOs – The finished product contains no detectable genetically-modified organisms

Vegan – The product is made without any ingredients produced or derived from animals

Checked For – Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity

CoreBiome^® (Tributyrin)
CoreBiome^® is a derivative of butyrate, which is a byproduct of the microbiota in our gut. A great source of butyrate is derived from the vegetables we eat, which nourish our bodies with fiber. However, the body cannot always break down the fibers as it moves through the digestive tract. This is where the microbiota step in – to break down these fibers that then ferment into butyrate, one of many short-chain fatty acids. SCFA support microbiome health by supporting a healthy microbiome and a balanced flora. By maintaining a healthy digestive environment and healthy intestinal barrier and permeability, butyrate plays a great role in supporting digestive, gut, and gastrointestinal health. CoreBiome^® is a great option for the picky eaters that may not consume optimal amounts of vegetables, and it is extra support for those who already do.

Berberine
Berberine is an isoquinoline plant alkaloid found in a variety of plants including barberry, Oregon grape, goldenseal, goldthread, and tree turmeric, with its history of use dating back to Ayurvedic and Chinese medicine. Studies have shown berberine to have both hypoglycemic and hypolipidemic properties, which helps maintain normal blood and cholesterol levels. Scientists believe that by upregulating the expression of LDL, berberine contributes to supporting healthy cholesterol levels. Similarly, berberine is thought to support healthy blood glucose levels. Additionally, berberine may support the production of akkermansia, a beneficial bacterium that has been reported to maintain healthy intestinal mucus secretion and thus support the intestinal barrier.

1. What gut bacteria are associated with butyrate SCFA production?
   Butyricicoccus pullicaecorum, Eubacterium rectale, Faecalibacterium prausnitzii and Roseburia spp. 
   
   
2. What is the connection between dietary fiber and blood sugar levels?
   Fiber is non-digestible and moves slowly through the digestive system. Although it is a carbohydrate, it does not convert into sugar, leaving you feeling fuller longer and helping to maintain blood sugar levels.
   
   
3. Who would benefit from this product?
   Those looking for direct postbiotic support or individuals who are interested in maintaining healthy communication between the gut-brain axis, which plays into the working systems of the body to support digestive health and the production of SCFA.
   
   
4. What is the difference between a prebiotic, probiotic and a post-biotic?
   Prebiotics are fiber or resistant starches that the body cannot digest. Instead, they are the fuel for probiotics and help support the growth of healthy bacteria in the gut. Probiotics are produced in the gut as fiber goes through the fermentation process within the large intestine and colon, or by eating foods that are fermented, such as sauerkraut, kefir, yogurt, goat cheese or kimchi. These “good” bacteria manufacture beneficial vitamins to prevent “bad” bacteria from entering the blood, which helps the body digest food by breaking its own for absorption. Postbiotics are short-chain fatty acids (SCFA) that may help support healthy cholesterol and help maintain healthy blood pressure levels. An imbalance in the microbiome can result in dysbiosis and affect your body. A well-balanced diet can help support your body’s beneficial bacteria, but supplementation may also be helpful to maintain regularity.
   
   
5. What other products would pair well with this supplement?
   Digestive health is important for overall wellbeing. Maintaining daily digestive health may be a priority for some, while others may only need occasional support. Probiotics-10, NutriClean® Probiotics, NutriClean® Advanced Fiber Powder or Daily Greens would also be ways to supplement for digestive and overall health support.
   
   
6. What are the three most common short-chain fatty acids (postbiotic metabolites) that are essential to the gut?
   Butyrate, acetate and propionate. The cells in the lining of the gut require butyrate to function properly. Butyrate gives energy to colonocytes (cells in the gut lining) which maintain an oxygen-free environment for beneficial gut microbes (or gut flora) to thrive. Keeping gut cells and bacteria happy and healthy. Acetate, the most abundantly produced by the gut, helps maintain the pH and keep gut acid levels low. Propionate assists in the production of glucose in the liver.
   
   
7. Why does the aging body benefit from butyrate?
   Over time the gut microbiome diversity changes. This results in one needing to pay more attention to proper diet, exercise and proper hydration. Even with a healthy diet, it may be necessary to supplement the gut to retain postbiotics such as butyrate to maintain a healthy gut lining.
   
   
8. Why should I use this product if I already have a high-fiber diet?
   Diets should consist of a good balance of healthy foods including fiber. It is recommended that healthy adults consume an average of 25 grams of fiber daily. Fiber is a carbohydrate but does not convert into sugar. Instead, fiber moves through the digestive system to help clean, giving a feeling of fullness and maintaining healthy blood sugar levels.
   
   
9. Are there any warnings associated with this product or the product’s ingredients?
   Prime Advanced Digestive Support is intended for adults 18 years and older. CoreBiome^® and Berberine are ingredients that are intended to maintain a healthy gut microbiome but may also contribute to changes in blood sugar. Do not take if you are allergic to any of the ingredients or are pregnant or breastfeeding. As with any change in supplementation, consult your primary physician before using.

• Dong, C., Yu, J., Yang, Y., Zhang, F., Su, W., Fan, Q., Wu, C., & Wu, S. (2021). Berberine, a potential prebiotic to indirectly promote Akkermansia growth through stimulating gut mucin secretion. Biomedicine & Pharmacotherapy, 139, 111595. https://doi.org/10.1016/j.biopha.2021.111595
• Rivière, A., Selak, M., Lantin, D., Leroy, F., & De Vuyst, L. (2016). Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut. Frontiers in microbiology, 7, 979. https://doi.org/10.3389/fmicb.2016.00979
• Cani, P. D., & de Vos, W. M. (2017). Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila. Frontiers in microbiology, 8, 1765. https://doi.org/10.3389/fmicb.2017.01765
• Robinson, M. (2022, March 9). CoreBiome® Tributyrin: The Source of Wellness. Compound Solutions. https://compoundsolutions.com/CoreBiome®-tributyrin-the-source-of-wellness/
• Ma, N., Tian, Y., Wu, Y. and Ma, X., 2017. Contributions of the Interaction Between Dietary Protein and Gut Microbiota to Intestinal Health. Current Protein and Peptide Science, 18, pp.795-808.
• Sauer J., Richter K.K., Pool-Zobel B.L. Physiological concentrations of butyrate favorably modulate genes of oxidative and metabolic stress in primary human colon cells. J Nutr Biochem. 2007;18:736–745.
• Stilling, R. et al. The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain-axis? Neurochemistry International 99 (2016) 110–132.
• Topping D.L., Clifton P.M. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev. 2001;81:1031–1064.
• Naito, Y., Uchiyama, K., & Takagi, T. (2018). A next-generation beneficial microbe: Akkermansia muciniphila. Journal of clinical biochemistry and nutrition, 63(1), 33–35. https://doi.org/10.3164/jcbn.18-57