Get the restful, recharging sleep your body and mind need with Prime™ Sleep! Make the most of your bedtime, wake up feeling vital, healthy, and refreshed, and be able to focus as you take on your daily demands.

Composed of complimentary ingredients such as valerian root extract, hops extract, and an effective amount of melatonin, Prime Sleep is formulated to help you with the total quality of your sleep.

Tossing and turning at night? The way you function overall when you’re awake depends on the sleep you’re getting. Hit that “reset” button with Prime Sleep, for your best rest and relaxation!

Promotes Sleep

• Promotes relaxation
• May improve sleep quality
• Helps you fall asleep
• May help you stay asleep

Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

Vegan - The product is made without ingredients produced by or derived from animals

Quality Standards - GMP Operations and Standardized Ingredients

Checked For: Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity

Valerian Root Extract (Valeriana officinalis)
Valerian is a perennial plant native to Europe and Asia and grown in North America, that can grow over 6 feet tall, with small pink to white flowers. The roots and rhizome of valerian are used in dietary supplements to promote sleep. Valerenic acid and other constituents of valerian may inhibit the enzyme system responsible for the central catabolism of gamma-aminobutyric acid (GABA), thereby supporting GABA concentrations and promoting relaxation. *  

Hops Extract (Humulus lupulus)
Hops are cone-like structures of Humulus lupulus, a vine that is native to Eurasia and temperate regions of North America. Humulus lupulus is also grown in parts of South America, South Africa, and Australia. The term "hops" originates from the Anglo-Saxon term "hoppan", meaning "to climb." Hops extracts and oils are used in food and beverage as flavor components and are also used in dietary supplements to promote sleep. Hops may promote relaxation effects by helping to promoting normal levels of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system. *

Melatonin
Melatonin is a neurohormone produced in the brain by the pineal gland.  The synthesis and release of melatonin are stimulated by darkness and suppressed by light, suggesting the involvement of melatonin in the circadian rhythm and regulation of diverse body functions. Levels of melatonin in the blood are highest prior to bedtime.  It is found in animals and, in much lower concentrations, in plants.  Melatonin is synthesized endogenously by the pinealocytes of the pineal gland, and the essential amino acid L-tryptophan is a precursor in its synthesis.  Melatonin supplementation has become popular to support sleep. It has also been known to assist with jet lag. *

L-Tryptophan
In the body, tryptophan is converted into 5-hydroxytryptophan, which then can be converted into serotonin. The body cannot naturally produce this amino acid; therefore, it must be a part of the diet or ingested through supplementation. Tryptophan is a component of many animal and plant proteins. Food sources of tryptophan are dairy products, beef, poultry, barley, brown rice, fish, soybeans and peanuts.

L-Theanine
L-Theanine is the major amino acid found in green tea, historically used for its relaxing effects. Theanine may work for relaxation by promoting normal levels of gamma-aminobutyric acid (GABA), serotonin and dopamine. In the central nervous system, GABA is the primary inhibitory neurotransmitter which promotes calming effects at the cellular level. Dopamine supports the normal regulation of many functions within the brain regarding behavior, cognition, sleep, mood, attention and memory.*

1. How much sleep do I need?
   Adults should try to get eight hours of sleep each night. More important than the exact length of time in bed is feeling rested when awakening and having energy throughout the day. If not, make changes to your sleep environment and allow more time for sleeping.
   
   
2. What are the benefits of good sleep?
   Sleeping well each night will reduce stress and irritability, improve your energy and concentration, and support your immune system.
   
   
3. Is Prime Sleep habit-forming?
   Prime Sleep should only be taken occasionally as needed to reduce the length of time it takes to fall asleep. If you feel the need to take Prime Sleep more than four nights in a seven-day period, you may have a serious sleep disorder and should consult your physician. *
   
   
4. Will this product cause next day drowsiness?
   As with all sleep aid supplements, there is a possibility to feel the effects the following day. However, if taken as directed, allowing adequate time for a full night's sleep you should feel well rested and ready for the day!*
   
   
5. Will this interact with any other supplements or medications I take?
   If you are currently taking medications that depress the central nervous system (antidepressants, anti-anxiety or antipsychotic agents), muscle relaxants, antihypertensive drugs, or anticonvulsants, fluvoxamine (Luvox), consult your healthcare provider before using this product. If you are currently using any other prescriptions drug or have an ongoing medical condition, consult your healthcare provider before using this product. If you are pregnant or breastfeeding, do not use this product. Do not mix with alcohol. Avoid use when driving or operating heavy machinery.
   
   
6. What causes the occasional inability to sleep?

• Stress
• Noise
• Extreme temperatures
• Jet lag — change in time zones
• Excessive amounts of caffeine
• Smoking cigarettes before bedtime
• Drinking alcohol before bedtime
• Expecting to have difficulty sleeping and worrying about it
• Irregular sleeping habits
• Excessive exercise close to bedtime

• Balderer G, Borbély AA. Effect of valerian on human sleep. Psychopharmacology (Berl). 1985;87(4):406‐409. doi:10.1007/BF00432503
• Cajochen C, et al, Daytime melatonin administration enhances sleepiness and theta/alpha activity in the waking EEG. Neurosci Lett 207(3): 208-213 (1996)
• Dollins AB, et al, Effect of pharmacological daytime doses of melatonin on human mood and performance. Psychopharmacology 112(4):490-496 (1993)
• Donath F, Quispe S, Diefenbach K, Maurer A, Fietze I, Roots I. Critical evaluation of the effect of valerian extract on sleep structure and sleep quality. Pharmacopsychiatry. 2000;33(2):47‐53. doi:10.1055/s-2000-7972
• Hartmann E, Spinweber CL. Sleep induced by L-tryptophan. Effect of dosages within the normal dietary intake. J Nerv Ment Dis. 1979;167(8):497‐499.
• Hartmann, E. and Spinweber, C. Sleep induced by L-tryptophan. Effect of dosages within the normal dietary intake. The Journal of Nervous and Mental Disease. 167(8): 497-499, 1979.
• Ito, K., et al. Effects of L-theanine on the release of alpha brain waves in human volunteers. Nippon Nogeikagaku Kaishi 72:153-157, 1998.
• Kobayashi, K., et al. Effects of L-theanine on the release of alpha-brain waves in human volunteers. Journal of the Agricultural Chemical Society of Japan. 72(2): 153-157, 1998.
• Körner E, Bertha G, Flooh E, Reinhart B, Wolf R, Lechner H. Sleep-inducing effect of L-tryptophane. Eur Neurol. 1986;25 Suppl 2:75‐81. doi:10.1159/000116087
• L-Theanine Monograph. Alternative Medicine Review 2005;10(2):136-138.
• Monograph. L-Tryptophan. Alternative Medicine Review. 11(1): 52-56, 2006.Valerian. TRC Natural Medicines. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=870. 4 June 2020.