As the body ages, many people experience joint discomfort. One option is to take a joint supplement to help promote overall bone and joint health. When looking at a joint supplement, there are three main ingredients found in most products on the market: glucosamine, chondroitin and methylsulfonylmethane, more commonly referred to as MSM.

The research on both chondroitin and MSM is very controversial. Chondroitin, for instance, has very poor absorption due to its high molecular weight. Also, one of chondroitin’s mechanisms is to increase the hyaluronic acid content of synovial fluid; while the new Prime Joint Support Formula by Isotonix directly provides hyaluronic acid. Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Likewise, research on MSM is not conclusive. In fact, it takes large quantities of MSM daily (2-6 grams) to make a difference and see effects.*

On the other hand, the research behind glucosamine is consistent and its benefits effective. Prime Joint Support Formula contains glucosamine, naturally produced by the body and a key component of cartilage. An aminomonosaccharide (a combination of the amino acid — glutamine and a sugar — glucose), glucosamine is concentrated in joint cartilage, and has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates your joints and regenerates cartilage.*

The natural aging process affects everyone and proper exercise, sleep and supplementation are essential for healthy living. Prime Joint Support Formula also contains the powerful antioxidant Pycnogenol®, which science has shown to help maintain the body’s natural defenses by inhibiting metabolic responses associated with the normal aging process. 

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.

‡Pycnogenol® is a registered trademark of Horphag Research Ltd. 

Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

No Detectable GMOs - The finished product contains no detectable genetically-modified organisms

Isotonic-Capable Drinkable Supplements - Easy-to-swallow supplements in liquid form are immediately available to the body for absorption

Quality Standards - GMP Operations and Standardized Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity

1. Why pay with an FSA or HSA card?
   Using your FSA or HSA card allows you to use pre-tax dollars to purchase eligible items. You still pay sales tax on purchases, but FSA and HSA cards enable you to pay directly using funds from your tax-advantaged account.
   
   
2. What is an FSA?
   A Flexible Spending Account (FSA) is an account you contribute to on a pre-tax basis to pay for certain out-of-pocket health care costs. The Internal Revenue Service (IRS) sets guidelines for individual benefit plans to determine eligible health care costs. As such, some items may or may not be eligible for FSA, depending on your specific benefit plan. 
   
   
3. Do my FSA funds expire?
   Yes. All remaining funds at the end of the benefit period are forfeited. 
   
   
4. What is an HSA?
   A Health Savings Account (HSA) is a medical savings account associated with your health plan and used to pay for certain out-of-pocket health care costs. Funds can be contributed to this account on a pre-tax basis. The Internal Revenue Service (IRS) sets guidelines for individual benefit plans to determine eligible health care costs. As such, some items may or may not be eligible for HSA, depending on your specific benefit plan.
   
   
5. Do my HSA funds expire?
   No, Funds in your HSA will roll over at the end of the year and continue accumulating. 
   
   
6. Are the same items eligible for an FSA account as an HSA account?
   Yes. FSA and HSA product eligibility are determined by the same IRS and benefit plan guidelines. Your benefit plan administrator determined which items are qualified for reimbursement. 
   
   
7. How should Prime Joint Support Formula by Isotonix be taken?
   On an empty stomach, take two capfuls daily or as directed by your healthcare professional.
   
   
8. What other products should I take with Prime Joint Support Formula by Isotonix to support my joint health?
   Heart Health™ Essential Omega III is a great pair with Prime Joint Support Formula, as omega III fatty acids have been shown to support healthy joint lubrication.
   
   
9. How often should I take Prime Joint Support Formula by Isotonix?
   This product is most effective when taken daily.
   
   
10. How much Pycnogenol® is in Prime Joint Support Formula by Isotonix?
    There are 25 milligrams of Pycnogenol in each daily serving.
    
    
11. What is the best way to store this product?
    Keep Isotonix stored in a dry, cool place. If Isotonix are stored in the kitchen, keep them away from the stove, sink, heat-generating appliances or window ledges. If you live in a very humid area, you may store Isotonix products in the refrigerator – but not in the fruit and vegetables area.

• James, C. and Uhl, T. A review of articular cartilage pathology and the use of glucosamine sulfate. Journal of Athletic Training. 36(4): 413-419, 2001.
• Julovi, S., et al. Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Arthritis and Rheumatism. 50(2): 516-525, 2004.
• Nakatani, S., et al. Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5. Biological and Pharmaceutical Bulletin. 30(3): 433-438, 2007.
• Ohno, S., et al. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. Journal of Biological Chemistry. 281(26): 17952-17960, 2006.
• Poustie, M., et al. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. 311(2): 610-616, 2004.
• Sasaki, A., et al. Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells. The Tohoku Journal of Experimental Medicine. 204(2): 99-107, 2004.
• Schäfer, A., et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol®). Biomedicine and Pharmacotherapy. 60: 5-9, 2006.